Uses
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YANGONIN

Uses
Product Name
YANGONIN
CAS No.
500-62-9
Chemical Name
YANGONIN
Synonyms
Yan;Y100550;YANGONIN;11-METHOXYYANGONIN;Yangoninpproved, it should be;4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-on;Yangonin, 98%, from Piper methysticum Forst;4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-one;4-Methoxy-6-((E)-4-methoxystyryl)pyran-2-one;4-methoxy-6-(beta-(p-anisyl)vinyl)-alpha-pyrone
CBNumber
CB4393593
Molecular Formula
C15H14O4
Formula Weight
258.27
MOL File
500-62-9.mol
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YANGONIN Property

Melting point:
155-157°
Boiling point:
487.6±45.0 °C(Predicted)
Density 
1.325 g/cm3
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
color 
Pale Yellow to Pale Green
BRN 
230710
Stability:
Light Sensitive
LogP
1.750 (est)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
75575
Product name
Yangonin
Purity
analytical standard
Packaging
5MG
Price
$501
Updated
2022/05/15
Cayman Chemical
Product number
14351
Product name
Yangonin
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
14351
Product name
Yangonin
Purity
≥98%
Packaging
5mg
Price
$180
Updated
2024/03/01
Cayman Chemical
Product number
14351
Product name
Yangonin
Purity
≥98%
Packaging
10mg
Price
$270
Updated
2024/03/01
Cayman Chemical
Product number
14351
Product name
Yangonin
Purity
≥98%
Packaging
25mg
Price
$595
Updated
2024/03/01
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YANGONIN Chemical Properties,Usage,Production

Uses

A lactone isolated from the Kava plant (Piper methysticum). The active constituents of Kava are a group of approx. 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements.

Description

Yangonin is a natural kavalactone from the kava plant, P. methysticum. It enhances the binding of bicuculline at the γ-amino butyric acid (GABA) receptor GABAA at 1.0 μM. Yangonin also binds the central cannabinoid (CB1) receptor with a Ki value of 0.72 μM, but whether it serves as an agonist or antagonist at this receptor remains to be determined. Yangonin blocks the activation of NF-κB by TNF-α. It also inhibits anchorage-dependent and independent growth of bladder cancer cell lines through induction of autophagic cell death (IC50s = 15-59 mg/mL).

Uses

A lactone isolated from the Kava plant (Piper methysticum). The active constituents of Kava are a group of approx. 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements.

Uses

A lactone isolated from the Kava plant (Piper methysticum). rokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety d isorders. a supplements.

Definition

ChEBI: Yangonin is a member of 2-pyranones and an aromatic ether.

YANGONIN Preparation Products And Raw materials

Raw materials

Preparation Products

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YANGONIN Suppliers

Canada 1 China 119 France 1 Germany 2 India 1 Switzerland 1 United Kingdom 4 United States 19 Global 148
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
ALB Technology Limited
Tel
702-983-3769
Fax
702-983-3769
Email
sales@albtechnology.com
Country
United States
ProdList
2993
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8449
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58
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View Lastest Price from YANGONIN manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Yangonin 500-62-9
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-02-25
Career Henan Chemical Co
Product
YANGONIN 500-62-9
Price
US $1.00/kg
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-25

500-62-9, YANGONINRelated Search:

L-KAWAIN FLAVOKAVAIN A(P) DIHYDROMETHYSTICIN Dihydrokawain 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE METHYSTICIN FLAVOKAWAINC Kavain YANGONIN(P),YANGONIN SNAP-N-SHOOT 0.1mg/mL(P) YANGONIN(PRIMARY STANDARD) 2-ACETOXY-1,3-BUTADIENE 4-Methoxy-6-methyl-2H-pyran-2-one DIHYDROKAVAIN DEHYDROMETHYSTICIN YANGONIN

  • YANGONIN
  • 11-METHOXYYANGONIN
  • 4-methoxy-6-(beta-(p-anisyl)vinyl)-alpha-pyrone
  • 4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-on
  • 4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-one
  • 5-hydroxy-3-methoxy-7-(p-methoxyphenyl)-2,4,6-heptatrienoicacidgamma-lacton
  • 4-Methoxy-6-[2-(4-methoxyphenyl)ethenyl]-2H-pyran-2-one
  • 4-Methoxy-6-[(E)-2-(4-methoxyphenyl)vinyl]-2H-pyran-2-one
  • 4-Methoxy-6-((E)-4-methoxystyryl)pyran-2-one
  • Yan
  • Yangoninpproved, it should be
  • Yangonin, 98%, from Piper methysticum Forst
  • Y100550
  • (E)-4-Methoxy-6-(4-methoxystyryl)-2H-pyran-2-one
  • 2H-Pyran-2-one, 4-methoxy-6-[(1E)-2-(4-methoxyphenyl)ethenyl]-
  • 500-62-9
  • 500-62-0
  • C15H14O4
  • Aromatics
  • Heterocycles
  • Mutagenesis Research Chemicals